Anatomy, Histologyو Embryology
Rahmat allah Fatahian dehkordi; Mohammad Javad Yazdanpanah; Reza Khetvan
Volume 28, Issue 2 , May and June 2021, , Pages 250-258
Abstract
Introduction: The aim of this study was to stereological evaluate of the protective effect of pancreatin on morphological changes in mice kidney after treatment with L-arginine .
Materials and Methods: To conduct research, 50 adult male rats weighing 30±2 gr were divided into 5 groups (equal). ...
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Introduction: The aim of this study was to stereological evaluate of the protective effect of pancreatin on morphological changes in mice kidney after treatment with L-arginine .
Materials and Methods: To conduct research, 50 adult male rats weighing 30±2 gr were divided into 5 groups (equal). In the control group, no administration was made. The pancreatitis induction groups received 2 doses of 300 and 400 mg/100 g body weight of L-arginine. To the induction groups with two different doses, therapeutic drug was prescribed 3.5 pp. of lipase-pancreatin. All treatments were received for 3 consecutive days once a day from L-arginine solution and 72 hours later, a lipase-pancreatin solution was administered to groups of pancreatitis for 20 days .
Results: The results showed that due to experimental pancreatitis, except for medulla volume, decreasing volume of renal cortex, proximal and distal convoluted tubules, and glomeruli was observed in the treated groups compared to the control group. By the administration of pancreatin lipase along with L-arginine, mean volume values of factors such as mean volume of renal cortex, proximal convoluted tubules and glomeruli, have gotten closed to the control group .
Conclusion: According to a final review of the findings, lipasepancreatin solution may be partially effective in mitigating the effects of pancreatitis induced by high doses of L-arginine